Research activity:
The group focuses on the application of advanced chemometric methodologies to address complex challenges in Analytical Chemistry. The research integrates multivariate analysis, experimental design (DOE) and data fusion strategies to extract meaningful information from high‑dimensional chemical systems.
Core expertise includes: multivariate analysis (PCA, MCR, PLS, supervised classification); multi-way chemometrics for three-way; multivariate optimization of processes and materials through DOE; predictive modeling for sensing devices and analytical measurements; chemometric strategies for electrochemical and spectroscopic systems; statistical approaches for understanding complex phenomena (solution equilibria, polymerization, material stability, food degradation).
Coordinator: Lisa Rita Magnaghi
Team:Raffaela Biesuz, Antonio Bova
Collaborations:
Onyax srl (Vigevano, Pavia),
Chemometric Solutions (Prof. Leardi, Dott. Farinini),
Università di Genova (Prof. Olivieri), Università di Modena e Reggio Emilia (Prof.ssa Cocchi e Prof.ssa Durante),
Università degli studi dell'Insubria (Prof.ssa Giussani)
Politecnico di Milano (Dott. Marcon)
Pubblications:
Magnaghi, L.R.*; Guembe-Garcia, M.; Cerone, V.; Perugini, P.; Alberti, G.; Biesuz, R. DOE-based multi-criteria optimization of starch/gly/CMC films’ composition and preparation procedure by casting deposition. Chemometr. Intell. Lab. Syst., 2024, 244, 105044 https://doi.org/10.1016/j.chemolab.2023.105044
Coduri, M.*; Magnaghi, L.R.; Fracchia, M.; Biesuz, R.; Anselmi-Tamburini, U. Assessing Phase Stability in High Entropy Materials by Design of Experiments: the Case of the System (Mg,Ni,Co,Cu,Zn)O. Chem. Mater., 2024, 36(2), 720-729 https://doi.org/10.1021/acs.chemmater.3c02120
Schifano, F.; Magnaghi, L.R.*; Monzani, E.; Casella, L.; Biesuz, R. Exploiting Principal Component Analysis (PCA) to reveal temperature, buffer and metal ions’ role in neuromelanin (NM) synthesis by dopamine (DA) oxidative polymerization. J. Inorg. Biochem. 2024, 256, 112548 https://doi.org/10.1016/j.jinorgbio.2024.112548
Betti, L.A.; Magnaghi, L.R.*; Bosetti, A.; Malavasi, L.*; Biesuz, R. Chemometric Approach for the Design of Lanthanum-based High Entropy Perovskite Oxides. J. Mater. Chem. C. 2024, 12, 7695-7706 https://doi.org/10.1039/D4TC00993B
Magnaghi, L.R.*; Guembe-Garcia, M.; Santonoceta, G.D.G.; Capucciati, A.; Quadrelli, P.; Sgarlata, C.; Alberti, G.; Biesuz, R. Exploring albumin-sulfonephthalein dyes interactions by a chemometric-assisted and multi-technique equilibria analysis in solution. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2024, 317, 124421 https://doi.org/10.1016/j.saa.2024.124421
Schifano, F.; Magnaghi, L.R.*; Sturini, M.; Monzani, E.; Casella, L.; Biesuz, R. Soft modeling strategies at work to follow and rationalize dopamine oxidative polymerization. Microchem. J. 2024, 204, 111141 https://doi.org/10.1016/j.microc.2024.111141
Zannotti, M.; Piras, S.; Magnaghi, L.R*.; Biesuz, R.; Giovannetti, R.* Silver nanoparticles from orange peel extract: Colorimetric detection of Pb2+ and Cd2+ ions with a chemometric approach. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2024, 323, 124881 https://doi.org/10.1016/j.saa.2024.124881
Pirota, V.*; Dello Stritto, A.; Magnaghi, L. R.; Biesuz, R.; Doria, F.; Mella, M.; Freccero, M.; Crespan, E. A Novel G-Quadruplex Structure within Apolipoprotein E Promoter: A New Promising Target in Cancer and Dementia Fight? ACS Omega 2024, 9(45), 45203–45213 https://doi.org/10.1021/acsomega.4c06430
Guerrini, M.; Magnaghi, L.R.; Fracchia, M.*; Riccardi, M.P.; Pigoni, G.; Debbi, G.; Patrini, M.; Biesuz, R.; Tarantino, S.C.; Anselmi Tamburini, U.; Ghigna, P. Minimizing the cobalt content in black ceramic pigments by Design of Experiments. Ceram. Int. 2024, 50(23), 51181-51191 https://doi.org/10.1016/j.ceramint.2024.10.033
Guembe-Garcia, M.; Magnaghi, L.R.*; Biesuz, R. Albumin quantification by alternative chemometric-assisted dye-binding methods robust towards pH and ionic strength variations. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2025, 332, 125821 https://doi.org/10.1016/j.saa.2025.12582
Magnaghi, L.R.*; Trigueros, E.; Biesuz, R. A Statistical Approach toward Biofilms Hydrophilicity Characterization: Integrating ANOVA, DOE, and PCA for Starch/Glycerol/CMC Films Case Study. ACS Appl. Bio Mater., 2025, 8 (5), 3691-3696 https://doi.org/10.1021/acsabm.5c00510
Bini, A.; Magnaghi, L.R.; Cavalloro, V.; Bonanni, A.; Protti, S.*; Merli, D.* Chemometric Optimization of BF3·OEt2-Mediated Cyclization of Cannabidiol to Rare ∆4- and Iso-THC Isomers. Chem. Eur. J., 2025, 0, e02387 https://doi.org/10.1002/chem.202502387
Guembe-Garcia, M.; Magnaghi, L.R.*, Franceschi, G.E.; Bova, A.; Biesuz, R. Multi-Way Data Analysis Nowadays: Taking Advanced Chemometric Tools to Everyday Analytical Chemistry Applications. Chemosensors, 2026, 14(2), 37 https://doi.org/10.3390/chemosensors14020037
Bova, A.; Magnaghi, L.R.*; Bonanni, A.; Quarta, G.P.; Biesuz, R. Chemometric strategy for online tap water conductivity monitoring by electrical impedance in distribution systems. Chemometr. Intell. Lab. Syst., 2026, 274, 105724 https://doi.org/10.1016/j.chemolab.2026.105724